NME2 and melanoma: The role of NME2 in metastases suppression is well-described: overexpression of NME2 results in reduced metastasis of human oral squamous carcinoma, breast carcinoma, and murine melanoma cells (17, –, 19), and the level of NME2 expression negatively correlates with advanced/metastatic stages in several tumor types (20).