TLR3 and cancer: Although SW480 cells did not express detectable levels of TLR3 and failed to respond to poly(I:C) addition, its metastatic counterpart, SW620 cells, up-regulated TLR3 and produced CXCL10 in a TLR3-dependent manner following poly(I:C) stimulation, suggesting that increased TLR3 expression could be a characteristic of progressed cancer.