CXCR3 and neoplasm: Elevated serum CXCL10 and increased expression of CXCL10 and CXCR3 in tumor cells have been associated with a poor prognosis and metastasis (50, 51, 56, –, 58), suggesting that the CXCL10–CXCR3 axis may promote CRC progression in some cases.