Although the chemokine CXCL10 is known to exert anti-angiogenic properties and mediate the recruitment of CXCR3-expressing mononuclear cells with anti-tumor activities, CXCL10 and its receptor CXCR3 are increasingly being recognized as pro-tumorigenic in several types of cancers, including CRC (55). The gene discussed is CXCR3; the disease is cancer.