The observation that TLR3 is expressed in the plasma membrane of metastatic epithelial cells and that TLR3-dependent CXCL10 induction can occur in response to extracellular stimuli suggests that malignant TLR3-expressing IECs could potentially respond to TLR3 ligands in the tumor microenvironment. Here, CXCL10 is linked to neoplasm.