ZBP1 and infection: In contrast, ZBP1‐Zα1α2mut‐expressing cells displayed higher viability after infection and behaved similar to the parental Zbp1−/− cells, while ZBP1‐Zα1mut and ZBP1‐Zα2mut cells showed intermediate phenotypes (Fig 1G and H), with a greater contribution to cell death of the Zα2 domain.