In addition, several cardiovascular imaging methods have been used to show that type 2 diabetes mellitus is associated with increased rates of CAD,22 silent myocardial ischemia,23 and silent myocardial infarction (MI) .24, 25, 26 Patients with type 2 diabetes mellitus have elevated levels of cardiac biomarkers including high‐sensitivity cardiac troponin T (hs‐cTnT) and amino terminal B type natriuretic peptide (NT‐proBNP), which appear to be associated with adverse cardiovascular outcomes including heart failure.27, 28, 29. This evidence concerns the gene NPPB and diabetes mellitus.