WT1 and WAGR syndrome: 1), the commoner ones fall into two major categories: those associated with genito-urinary malformation because of underlying abnormalities in the WT1 gene (WT with Aniridia, Genitourinary abnormalities and mental Retardation (WAGR) syndrome; Denys–Drash syndrome (DDS)) and those associated with an overgrowth phenotype [Beckwith–Wiedemann syndrome (BWS) and Perlman syndrome].