In a separate study where CTNNB1 mutations were specifically studied in a patient with germline WT1 mutation and bilateral WTs, both tumours had a second WT1 hit of loss of heterozygosity (LOH), while the right tumour had delta45S CTNNB1 mutation and the left side had S45P in all cell types and a T41A CTNNB1 mutation specific to a separately microdissected stromal component (Ref. This evidence concerns the gene WT1 and neoplasm.