The differing roles for WT1 are further supported by the difference in clinical phenotype observed in patients with WT1 loss and WT1 mutation; a dominant-negative effect is predicted for intragenic WT1 point mutations because of the more severe genitourinary phenotype observed in patients with DDS in comparison with patients with complete WT1 deletion (WAGR syndrome). The gene discussed is WT1; the disease is WAGR syndrome.