Effects of the inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL6) that are triggered by excessive adipose tissue have been reported on insulin signaling pathways, resulting in insulin resistance and eventually progressing to type 2 diabetes mellitus (T2DM) [3, 4]. Here, INS is linked to type 2 diabetes mellitus.