CDK16 and hepatocellular carcinoma: The highest expression of CDK16 was found in HCC with portal vein tumor thrombus (PVTT) we also found that higher expression of CDK16 was closely correlated with multiple clinical pathological features including Edmondson grade (P = 0.023), encapsulation (P = 0.020), tumor number (P = 0.042) and PVTT (P = 0.029) (Table 1).