SPEN, PRODH2, IGSF10, MTNR1B and SMARCE1 were found to be mutated in 0.49% (1/203) of esophageal cancers, 0.41% (1/246) of endometrial cancers, 0.52% (1/194) of cervical cancers, 0.26% (1/391) of pancreatic cancers and 0.55% (1/183) of melanomas, in the International Cancer Genome Consortium (ICGC) database (http://icgc.org/, release 22). The gene discussed is SPEN; the disease is familial pancreatic carcinoma.