STAT1 has also been shown to be a negative regulator of hepatic fibrosis, where IFN-γ treatment of Stat1+/+ mice did not result in fibrosis while the same treatment of Stat1−/− mice resulted in increased hepatic fibrosis and accelerated TGF-β1/Smad signaling [26]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.