Examples include combinations with radiation and androgen-deprivation therapy in prostate cancer, radiation therapy and temozolomide in GBM, rapamycin in peripheral nerve sheet tumors, paclitaxel and eribulin in breast cancer, vemurafenib in melanoma, and KIT inhibitors in gastrointestinal stromal tumors (GISTs). The gene discussed is KIT; the disease is Familial prostate cancer.