In keeping with our findings is the evidence that telomerase reactivation during cancer cell immortalization may occur through the impairment of the p53-p21waf1 pathway caused by the overexpression of miR-296, which was found up-regulated in telomerase-positive cancer cells [23] as well as that miR-375-mediated suppression of multiple oncogenic factors resulted in TA inhibition as a consequence of p53-p21waf1 accumulation in HPV-associated cancer cells [24]. This evidence concerns the gene TP53 and cancer.