CASC2 and hepatocellular carcinoma: Meanwhile, The data from R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl) including GEO and TCGA database showed that the expression of CASC2 was significantly downregulated in HCC tissues compared to normal liver tissues (P < 0.05, respectively, Additional file 1: Fig. S1), which were consistent with our results.