With a prevalence of 1 in 10,000 individuals Marfan’s syndrome, an autosomal dominant disorder first clinically described in 1896 by Antonin-Bernard Marfan and genetically confirmed in the early 1990s, is caused by a mutation of the fibrillin-1 gene (FBN1), which maps to chromosome 5q21.1. Here, FBN1 is linked to Marfan syndrome.