However, following HIF induction by DMOG, a significant increase in BHLHE41 mRNA was observed in cells that carried at least one RCC-risk allele at the rs12814794 SNP, whilst the expression and induction of an control HIF target gene at an independent locus (EGLN3) was unaffected by the rs12814794 genotype (Fig 6A and 6B). Here, BHLHE41 is linked to renal cell adenocarcinoma.