BHLHE41 and renal cell adenocarcinoma: Having shown that the RCC-associated polymorphism underlying the chr 12p12.1 HIF-binding site influences binding of HIF, we next tested for effects on expression of the transcriptional target, BHLHE41. We first identified individuals who were heterozygous for a SNP (rs1048155) in the 3’ UTR of the BHLHE41 gene (Fig 5A).