Such a possibility is suggested by the RCC-associated locus at chr 12q24.31, which lies within the first intron of the gene encoding the lipoprotein scavenger receptor class B member 1, SCARB1. Whilst the index RCC-associated GWAS SNP at this locus, is close (approximately 2 kb) to an adjacent HIF-ChIP-seq signal, SNPs in high linkage with the index SNP do not overlap it precisely [2,7] (S8 Fig). The gene discussed is SCARB1; the disease is renal cell adenocarcinoma.