HIF-binding sites were defined by ChIP-seq analysis in two RCC cell lines (RCC4 and 786-O) and were present in a minimum of two out of 5 data sets (RCC4—HIF-1α, HIF-1β, HIF-2α and 786-O—HIF-1β, HIF-2α) [7,8]. This evidence concerns the gene HIF1A and renal cell adenocarcinoma.