In keeping with this, we observed that SCARB1 is a HIF transcriptional target in 786-O cells (S8A Fig), that its expression is upregulated in RCC tumor material when compared with surrounding normal kidney (S8B Fig), and that the risk polymorphism (at chr 12q24.31, [2]) is quantitatively associated with increased expression in ccRCC tumors in data from TCGA (S8C Fig). Here, SCARB1 is linked to renal cell adenocarcinoma.