However, the extensive bilateral thalamic calcifications that we observed in mice lacking Htt are more reminiscent of what is observed in mouse models of a series of rare diseases known as Familial Idiopathic Basal Ganglia Calcifications (FIBGC), cerebroferrocalcinosis/Fahr disease or Primary Familial Brain Calcification (PFBC). Here, HTT is linked to bilateral striopallidodentate calcinosis.