SBDS and acute lymphoblastic leukemia: Indeed, we recently found that both rpl10-S104D and rpl10-R98S ribosomes had a weakened affinity for Sdo1 compared to wild-type ribosomes in vitro [41,42], while others have also demonstrated that the T-ALL associated RPL10 alleles impair Sdo1 binding to the 60S subunit in vivo [34].