CD4 and influenza: CD8+ T‐cell epitopes for internal genes and CD4+ T‐cell epitopes for HA were mostly studied for epitope‐based vaccine design.19, 22, 44, 45 Studies showed that influenza HA does have conserved CD8+ T‐cell epitopes.21, 46 While our results have focused on the predicted CD8+ T‐cell epitopes, a high proportion of the predicted epitopes overlapped with experimentally confirmed CD4+ T‐cell epitopes.