EGF and breast carcinoma: We do know that EGF stimulation enhances the mitochondrial localization of EGFR and decreases cellular ATP in breast cancer cells,5 and that the mitochondrial translocation of EGFR enhances NSCLC cancer cell invasion and metastasis by regulating mitochondrial dynamics.6 Moreover, ErbB2, another member of the EGFR protein family, reportedly translocated into mitochondria and regulates cellular metabolism in breast cancer.7 These studies suggest that the localization of EGFR to mitochondria can affect cellular metabolism related to tumorigenesis.