In TSP1 or TSP2-deficient murine cardiac remodeling models (i.e., those affected with doxorubicin-induced cardiomyopathy [51], diabetic cardiomyopathy [52,53], dilated cardiomyopathy [54], or MI [44,55,56] the profibrotic role of both TSPs was confirmed. This evidence concerns the gene THBS2 and dilated cardiomyopathy.