LKSL-dependent suppression of TGF-β activation further aggravated abdominal aortic aneurysm associated with increase of aortic diameter, adverse atherosclerosis within the aortic arch, and aortic elastin fragmentation due to down-regulation of the TGF-β-target gene lysyl oxidase-like 1 (LOXL1), an enzyme involved in cross-linking of elastin [221]. Here, TGFB1 is linked to abdominal aortic aneurysm.