VEGFA and pachyonychia congenita: PC inflammation can promote PC through immunosuppression of cells in the TME through several mechanisms: (1) subversion of the T cell-mediated immune response by induction of immunosuppressive myeloid derived suppressor cells (MDSCs) [44], (2) inflammation induced, reversible loss of tumor-specific antigens [45], and (3) pro-inflammatory tumor-associated macrophages (TAMs) [46] that release immunosuppressive cytokines, including vascular endothelial growth factor (VEGF) [47], resulting in increased angiogenesis and metastasis [48,49].