Loss of SWI/SNF subunits leads to deregulation of tumor-associated pathways such as Wnt/β-catenin or Hedgehog/GLI [12,13] and deregulation of epigenetic modulators such as histone deacetylases (HDAC) and Enhancer of Zeste Homolog 2 (EZH2) [7,14]. The gene discussed is EZH2; the disease is neoplasm.