The rs58542926 C > T genetic variant of the transmembrane 6 superfamily member 2 gene (TM6SF2), encoding the E167K variant, is another determinant of hepatic triglyceride content [32] and the full spectrum of liver damage linked to hepatic fat accumulation, including NASH, necroinflammation, and fibrosis. This evidence concerns the gene TM6SF2 and metabolic dysfunction-associated steatohepatitis.