Recent multitarget-directed ligand (MTDL) approaches in medicinal chemistry have combined inhibitors of cholinesterases (ChE) and monoamine oxidases (MAO) to combat the loss of neurotransmitters in Alzheimer’s disease (AD), or of MAO with properties such as antioxidant and metal complexation for Parkinson’s disease (PD). The gene discussed is BCHE; the disease is Alzheimer disease.