Indeed, while in control corneas CD34+/PDGFRα+ TC were typically found in the whole corneal stroma (Fig. 3D–F), in keratoconus a patchy loss of CD34/PDGFRα immunoreactivity was observed mainly in the subepithelial part of the stroma (Fig. 3G–I). Here, PDGFRA is linked to keratoconus.