The results showed that GSK‐3β activity index was significantly increased in CRSsNP comparing with controls (P < 0.05) (Fig. 4), and GSK‐3β activity index and NF‐κB protein abundance were highly correlated in CRSsNP (r = 0.739, P < 0.01) (Fig. 5A). Here, GSK3B is linked to chronic rhinosinusitis without nasal polyps.