To evaluate the relationship between GSK‐3β activity index and chronic inflammation in CRSsNP, we detected the mRNA expression of inflammation‐related genes (T‐bet, RORC, GATA3, IFN‐γ, IL‐4, IL‐5, IL‐13, and IL‐17A). This evidence concerns the gene IL4 and chronic rhinosinusitis without nasal polyps.