To evaluate the relationship between GSK‐3β activity index and chronic inflammation in CRSsNP, we detected the mRNA expression of inflammation‐related genes (T‐bet, RORC, GATA3, IFN‐γ, IL‐4, IL‐5, IL‐13, and IL‐17A). The gene discussed is IL5; the disease is chronic rhinosinusitis without nasal polyps.