As the disruption of the N/C interaction has been implicated in the regulation of nuclear receptor activity, ligand sensitivity and subcellular localization34, 35, 51, 52, 53, our illustration of the existence of the N/C intramolecular interaction in RXRα provides a molecular explanation for the oncogenic effect of tRXRα in tumour cells29. This evidence concerns the gene RXRA and neoplasm.