To study whether the anti-tumour effect of K-80003 could be attributed to its effect on the subcellular localization of tRXRα in vivo, we stably transfected tRXRα or RXRα into MCF-7 cells, and the resulting stable clones (Supplementary Fig. 8a) were inoculated into nude mice. The gene discussed is RXRA; the disease is neoplasm.