Moreover, we have identified two combination strategies through unbiased HTS, that is, combining ABT-263 with anthracyclines such as doxorubicin or with CDK9 inhibitors such as dinaciclib, which induced potent apoptosis in all examined SCLC cell lines regardless of their dependency on different anti-apoptotic BCL-2 members for survival (Fig. 7a). This evidence concerns the gene CDK9 and small cell lung carcinoma.