The contrast of associations and genes across ancestries documents numerous ethnic-specific associations the ancestral diversity in SLE etiology; for example, HA regions not showing equivalent associations in EA include 3p11 (EPHA3-PROS1), 6q25 (RSPH3), 12q15 (DYRK2-IFNG), 12q21 (SYT1), 14q31 (GALC), 16q21 (CSNK2A2-CCDC113) and 22q12 (C1QTNF6). This evidence concerns the gene DYRK2 and systemic lupus erythematosus.