To address the contribution of circulating and Trm CD8+ T cells to control tumour growth, mice were infected with rVACV-OVA by s.s. or i.p. and, after generation of resident and/or circulating memory from the endogenous repertoire 30 days later12, were inoculated intradermally (i.d.)with B16-OVA cells (Fig. 2a). This evidence concerns the gene CD8A and neoplasm.