In contrast, a patient with acute lymphocytic leukemia, who had refractory brain MDR-TB and did not respond to anti-TB drugs and steroid treatment for 11 months, showed improvement in brain and chest radiographic alterations after 5 months of adjunctive therapy with IFN-γ administered subcutaneously; and complete resolution of the lesions in the brain and spinal cord were obtained after 12 months of therapy [63]. This evidence concerns the gene IFNG and tuberculosis.