SERPINE1 and atrial fibrillation: AF has been associated with hypofibrinolysis due to increased levels of plasminogen activator inhibitor type 1 (PAI-1) [17], although in other studies hyperfibrinolysis with elevated tissue plasminogen activator (t-PA) [18–22] and plasmin-α2-antiplasmin (PAP) complex levels were found [23].