Mutation of other epigenetic regulators, such as TET2 [14], MLL [15], IDH1/2 [16], FLT3 [11], NPM1 [11], RUNX1 [17], and ASXL1 [18], has been associated with unfavourable clinical outcomes for AML patients [7]. The gene discussed is NPM1; the disease is acute myeloid leukemia.