Most importantly, the reduction in the rate of progression of CKD by tight BP control was demonstrated by the Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of Chronic Renal Failure in Pediatric Patients (ESCAPE) trial where intensified ABPM-guided HTN therapy over a 5-year period led to a 35% reduction in subjects with 50% decline in renal function or progression to end stage renal disease (52). Here, ACE is linked to chronic kidney disease.