The human acute myeloid leukemia cell line MUTZ-3 can be differentiated in vitro to dermal DC in the presence of GM-CSF, TNF-α and IL-4, and to LC in the presence of GM-CSF, TNF-α and TGF-β (Santegoets et al., 2008). The gene discussed is CSF2; the disease is acute myeloid leukemia.