SMO and meningioma: The finding that no genes other than NF2 were significantly mutated in high-grade meningiomas suggests that high-grade meningiomas are much less likely to harbor mutations in known drivers of low-grade meningioma, including TRAF7, KLF4, AKT1, or SMO. To evaluate this possibility, we sequenced these genes, which are the four most common non-NF2 driver alterations, in our extension cohort of 76 samples.