2011; Lee et al. 2011; Sand et al. 2012). The potential role of KCTD12 in neuropsychiatric disorders is further supported by altered response to fear conditioning in KCTD12 knockout mice (Cathomas et al. 2015). However, other GABABR implicated diseases such as altered brain excitability and alcohol abuse have not been explored. The gene discussed is KCTD12; the disease is alcohol abuse.