F10 and acute coronary syndrome: It is likely that the decreased bleeding with dabigatran compared with warfarin observed in RE-CORD, RE-CORD II, and RE-MEDY outweighs any small increase in acute coronary events; however, the oral factor Xa inhibitors offer the same safety advantage over warfarin and, in contrast to dabigatran, have not been associated with an increased risk of acute coronary syndrome.