In vitro studies with the peripheral blood mononuclearcells (PBMCs) from healthy donors and patients undergoing severe sepsis showedincreased Th17 cells in patients with sepsis when compared with healthy donors.Additionally, IL-17 neutralization increased IL-10 production in PBMCs, suggesting arole for IL-10 in modulating immune responses during sepsis 104. The gene discussed is IL17A; the disease is Sepsis.