CFP-granulomas significantly bigger than mBSA-granulomas, CD8+ T-cells dominating, reduced DTH and antibody titers. Upon treatment with INN or Indomethacin; significant reduction of granuloma size, increase in DTH and antibody titers. mBSA-granulomas, composed quite equally of CD8+ and CD4+ T-cells, did not alter antibody titers. The gene discussed is CFP; the disease is Granuloma.