IFNG and in situ carcinoma: Analysis of the subgroup of patients expressing high IL-17F levels revealed significantly lower IFN-γ/IL-17F ratios in RRMS and PPMS than in CIS (p = 0.0157 and p = 0.0424, respectively) and HC (p = 0.0007 and p = 0.0421, respectively; Figure 2B).