IFNG and in situ carcinoma: Levels of IFN-γ significantly discriminated patients with CIS from MS, RRMS, and HC [area under curve (AUC) = 0.76, 0.80, and 0.84, respectively], RRMS from SPMS (AUC = 0.74), and PPMS from HC (AUC = 0.91).