IFNG and in situ carcinoma: Interestingly, the comparison of median values of the IFN-γ/IL-17F ratio among CIS and different MS stages (Figures 2A,B) suggests that MS might skew from a Th1 phenotype toward a Th17 as disease progresses from CIS (all group median = 290.8, subgroup median = 54.6) into RRMS (all group median = 120.7, subgroup median = 0.7) or PPMS (all group median = 160.8, subgroup median = 3.1).