*Adult mice lacking Ifnlr1 in all cells exhibit higher viral shedding of reovirus*Suckling mice lacking Ifnlr1 in all cells exhibit higher viral shedding and tissue titers of reovirus, increased tissue damage and severe mortality*Mice lacking Ifnlr1 exhibit higher reovirus infection in IECs, while mice lacking Ifnar1 exhibit higher infection in lamina propria cells. Here, IFNAR1 is linked to Reoviridae infectious disease.