PIK3CD and systemic lupus erythematosus: Another recently developed p110δ inhibitor, AMG319, reduced KLH-specific IgM and IgG production in vivo (10) while duvelisib (IPI-145), a dual p110δ/γ inhibitor, showed potent activity in reducing inflammation in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models (11).