To determine which risk factors for prediabetic state, including age, race, gender, CM score, depression score, visceral fat mass, TNFα, and CRP, were most predictive of metabolic abnormalities, stepwise multiple regression analyses were performed with these risk factors as the independent variables, and glucose area under the OGTT curve, HOMA-IR, and DIOGTT as the dependent variables in the models. The gene discussed is CRP; the disease is major depressive disorder.