Furthermore, Patil and collaborators showed that LiJ extracted in different solvents including acetone, chloroform and methanol, modulates the expression of caspase-3, Bax, Bcl-2, and p53, thus inducing apoptosis in Panc-28 pancreatic cancer cell line (Patil et al., 2009). Here, TP53 is linked to familial pancreatic carcinoma.