NOS2 and infectious otitis media: Madrigal-Bujaidar and co-workers showed that GJ suppressed the colon carcinogenesis induced by AOM in mice, by up-regulating apoptosis and reducing both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthases (iNOS) levels, thus suggesting even its anti-inflammatory activity (Madrigal-Bujaidar et al., 2013).