BDNF and Cognitive impairment: Similarly, even under neuropathological conditions, such as AD, voluntary physical exercise impeded the cognitive deficits and improved sensorimotor function in the AD triple transgenic mouse model (3xTg-AD) through various physiological mechanisms, including reducing oxidative stress, maintaining redox homeostasis and up-regulating BDNF in the brain (García-Mesa et al., 2014).