UCHL1 and Parkinson disease: Intriguingly, the mTOR inhibitor-Rapamycin treatment resulted in the induction of Uchl1 protein by association of shuttling Uchl1-AS from the nucleus to the cytoplasm, indicating the interplay among Uchl1-ncRNA-mTOR might be crucial for the development of PD (Carrieri et al., 2012; Vučičevič et al., 2014).