TRANK1 and Amelo-cerebro-hypohidrotic syndrome: By mapping them to the synaptic p140Cap interactome, our study provides functional cues on these disease genes, including ROGDI, FRMD4A, and TRANK1. Loss of ROGDI, encoding a protein with unknown function, causes Kohlschutter-Tonz syndrome (MIM 614574), which presents with psychomotor delay, early-onset intractable seizures, variable ID correlating with the severity of seizures, and amelogenesis imperfect (Schossig et al., 2012).