CACNA2D1 and epilepsy: CACNA2D1 and CACNA2D2 are both associated with epilepsy and ID (Edvardson et al., 2013; Pippucci et al., 2013; Vergult et al., 2015), while CACN2D3 has been recently implicated in ASD (De Rubeis et al., 2014).