During neurodegeneration, Tau undergoes post-translational modifications, truncations and aggregation, and has been identified as the main component of neurofibrillary tangles common in AD and other tauopathies (Goedert et al., 1988; Kondo et al., 1988; Wischik et al., 1988a,b; Kovacech and Novak, 2010; Iqbal et al., 2013; Falcon et al., 2015; Min et al., 2015; Houck et al., 2016; Wang and Mandelkow, 2016). The gene discussed is MAPT; the disease is tauopathy.