The astrocytic-restricted localization of S100B during the progression of the disease is consistent with the expression pattern of the molecule in other neurodegenerative diseases, such as HD [37] and PD [20], but differs from AD where, in the double-transgenic PS/APP model, S100B also stains Iba1-positive cells [38]. The gene discussed is AIF1; the disease is neurodegenerative disease.