In ALS, different indications point to an aberrant expression of S100B: in patients, S100B is increased in astrocytes in the cortex [21], in astrocytes, and motor neurons in the spinal cord [22] and its levels are also raised in the cerebrospinal fluid (CSF), positively correlating with a worse prognosis of the disease [23]. The gene discussed is S100B; the disease is amyotrophic lateral sclerosis.