Over the last decade, RAGE has gained attention as a regulator of innate and adaptive immunity in different pathologies associated with neuroinflammation, such as AD, PD, Huntington's disease (HD), Creutzfeldt-Jacob disease (CJD), diabetic neuropathy, and Charcot neuroartropathy (for review [34]). The gene discussed is AGER; the disease is diabetic neuropathy.