Over the last decade, RAGE has gained attention as a regulator of innate and adaptive immunity in different pathologies associated with neuroinflammation, such as AD, PD, Huntington's disease (HD), Creutzfeldt-Jacob disease (CJD), diabetic neuropathy, and Charcot neuroartropathy (for review [34]). This evidence concerns the gene AGER and Creutzfeldt Jacob disease.