TARDBP and amyotrophic lateral sclerosis: While aggregates formed from C-terminal fragments or the full-length protein do not react with Congo Red, another dye used to confirm that aggregates are amyloid [23], two recent studies have found that the fluorescent dye Thioflavin-S, that also binds to amyloid species, binds to TDP-43 positive skein-like inclusions in a subset of ALS cases, suggesting that pathological TDP-43 aggregates may in fact have amyloidogenic properties [24], [25].